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Dr Prabal Chatterjee

Dr Chatterjee is currently a Principal Lecturer and MSc Course Leader at the University of 映客直播, a Fellow of the American Society of Nephrology (FASN), British Pharmacological Society (FBPhS) and the Higher Education Academy (FHEA) and a committee member of the Renal Scientists Working Party (RSWP) of the UK Renal Association.

He currently runs an active renal research group, consisting of PhD students and postgraduate and undergraduate researchers which investigates the cellular mechanisms of Acure Kidney Injury (AKI) and Chronic Kidney Disease (CKD) and novel pharmacological and therapeutic interventions.

Dr Chatterjee’s latest research has investigated the potential protective role of a new carbon absorbent which could eventually be taken orally by CKD patients to lower blood levels of uraemic toxins which are derived from the diet and are difficult to remove by dialysis and accumulation of which contributes to the increased risk of cardiovascular disease.

Dr PK (Charley) Chatterjee
Principal Lecturer in Pharmacology

How I like to teach

I have over 10 years of teaching experience and I am a strong believer in research-informed teaching based on over 20 years of research. My teaching style involves breaking down complex subjects into basic components and then building these back up to help develop an understanding of the material being taught. I teach a wide range of students from first-year undergraduates to senior postgraduates. These include undergraduate students on BSc and MPharm courses as well as students at the 映客直播 and Sussex Medical School. My postgraduate teaching involves giving lectures to students on several MSc courses and well as Diploma Pharmacy and Industrial Science students and also Independent Prescribers and Nurses.

I try to make my lectures as interesting as possible and relevant by linking the subject matter to current news, events and the most recent research. This means that my lectures are quite visual and involve a lot of images with less text. Teaching with enthusiasm also helps!

I also believe that practical experience reinforces learning so my teaching is supported by practical classes and opportunities to undertake research. This research style seems to suit the majority of my students and the feedback obtained has often been highly positive.

However, I am always looking for ways to improve my teaching and am willing to try out different formats and introduce new concepts. My role as an External Examiner at other Universities allows me to see how things are done elsewhere and if they work, I can incorporate these features into my teaching.

My areas of teaching range from Introductory Pharmacology and Renal Physiology and Pharmacology right through to lectures on Mechanisms of Disease. My teaching is also supported by presentations to research colleagues, at local, national and international conferences and also at fund-raising events for national charities which support my research. I also have a Postgraduate Certificate in Higher Education (PGCertHE), awarded by the University of 映客直播 in 2004, and am a Fellow of the Higher Education Academy (FHEA). In 2011, I was 'Highly Commended' as 'The Most Supportive Postgraduate Tutor/Supervisor' at the 映客直播 Students’ Union Excellence Awards.

Research interests

My research involves investigation and understanding of the cellular mechanisms underlying the development of AKI and CKD (including diabetic kidney disease) along with investigation of novel pharmacological and therapeutic interventions.

Specifically, my research areas include

all aspects of renal physiology, pharmacology, injury and disease
the development of models of acute kidney injury (AKI) and chronic kidney disease (CKD) including diabetic kidney disease,
the investigation of the cellular mechanisms underlying the development of renal failure and disease
the role of oxidative stress and endoplasmic reticulum stress in the development of renal failure and disease
the development and characterisation of novel pharmacological interventions against ischemic and nephrotoxic renal failure and diabetic nephropathy.

Research activity

Current research projects

Investigation into the effects of dietary antioxidants against oxidant Induced acute kidney Injury (PhD project – Ben Elisha Lambert)
Investigation of the antioxidant and antidiabetic effect of aqueous leaf extracts of Mucuna Pruriens (PhD project – Oke-Oghene Akpoveso)
An Investigation of the uptake of glucose into renal proximal tubular cells (MSc project – Zarariya Al-Mashhadani)
Investigation into the renal cell toxicity of the uraemic toxin indoxyl sulphate (MPharm projects x 5)

Previous research projects

A Pilot Study to Investigate the Effects of Oral Mesoporous Carbon on Organic Azotaemic Toxins and Chronic Kidney Disease (Innovation Project Grant funded by Kidney Research UK – Lead Investigator: Dr PK Chatterjee)
The protective effects of caffeine and its metabolites in renal cell cultures exposed to paraquat (Intercalating Student Award from Kidney Research UK awarded to Sarah Dyball)
An Investigation of Ethanol Preconditioning of Rat Renal NRK-52E Cells (Intercalating Student Award from Kidney Research UK awarded to Rachel Morris)
Oxidant and antioxidant effects of fetuin-A/α2-Heremans-Schmid glycoprotein (AHSG) and its transport across renal proximal tubular epithelial cells (Intercalating Student Award from Kidney Research UK awarded to Luke Holland)
Oxidative and Endoplasmic Reticulum Stress in the Kidney (PhD studentship joint award to Elias Katsoulieris by Kidney Research UK and Diabetes UK)
An Investigation of Endoplasmic Reticulum Stress in Renal Proximal Tubular Cells and its Relevance to Nephrotoxic Acute Renal Failure. (Wellcome Trust Vacation Scholarship Awarded to Alex Dunn)
Novel Superoxide Dismutase Mimetics for Protection against Paraquat Nephrotoxicity (PhD studentship awarded to Mohamed Samai by the Commonwealth Scholarship Commission)

Social media links

Contact me

Pharmacy and Biomolecular Sciences
Moulsecoomb
映客直播
BN2 4GJ

Telephone: +44 (0)1273 643590

Email: P.K.Chatterjee@brighton.ac.uk

Biography

I have been involved in kidney research for over 20 years. I am particularly interested in understanding what goes wrong in the kidneys of patients who develop acute kidney injury (AKI) or chronic kidney disease (CKD) including diabetic kidney disease which is now the leading cause of CKD worldwide, and how this knowledge can be used to develop new medicines and therapeutics for these life-threatening conditions.

My interest in renal research began during my BSc degree in Pharmacology which I completed at the University of Liverpool in 1990 during which I completed a laboratory project during my final year looking at the detrimental effects of uraemic toxins which build up in the blood of patients with CKD and how these can affect the activity of medicines. After working for Glaxo Group Research in London, I moved to Aberdeen, Scotland where I completed a MSc by research investigating the electrophysiological characteristics of renal cells followed by a PhD in Medicine looking investigating the effects of the then novel gas, nitric oxide, and how it could be generated by human kidney cells during AKI. In 1998 I moved to London to work as a Research Scientist at the William Harvey Research Institute (WHRI) at Barts and the Royal London Hospital where we developed models of both AKI and CKD and used these to investigate potential new medicines such as antioxidants and enzyme inhibitors. This research was particularly successful leading to several key highly-cited research publications and other related research studies many of which are still on-going at the WHRI and elsewhere.

In 2003 I moved to the University of 映客直播 to take up the position of Senior Lecturer in Pharmacology which still involves teaching Pharmacy and Medical School students about renal physiology and pharmacology. I currently run an active Renal Research group, consisting of PhD students and postgraduate and undergraduate researchers where we investigate the cellular mechanisms of AKI and CKD and novel pharmacological and therapeutic interventions. Grants obtained from Kidney Research UK (KRUK) and Diabetes UK have allowed us to fund PhD and intercalating medical school students who have investigated the role of high glucose in diabetic kidney disease and other small research projects. Our latest research has investigated the potential protective role of a new carbon absorbent which could eventually be taken orally by CKD patients to lower blood levels of uraemic toxins which are derived from the diet and are difficult to remove by dialysis. The build up of these uraemic toxins in the blood of CKD patients leads to the increased risk of cardiovascular disease. The promising results of this research, which was funded by a KRUK Innovations Project grant, is currently being followed up.

I am currently a Principal Lecturer and Course Leader at the University of 映客直播, a Fellow of the American Society of Nephrology (FASN), British Pharmacological Society (FBPhS) and the Higher Education Academy (FHEA) and a committee member of the Renal Scientists Working Party (RSWP) of the UK Renal Association.

Research output

PhD students

Name	Thesis
Benjamin Elisha-Lambert (2013-2016):	An Investigation into the Effects of Dietary Antioxidants against Oxidant Induced Acute Kidney Injury
Oke-Oghene Akpoveso (2013-2016)	An Investigation of the Antioxidant and Antidiabetic Effect of Aqueous Leaf Extracts of Mucuna Pruriens
Martin Ford (2008 – 2012)	The Role of Calcification Regulatory Proteins in the Arterial Stiffening of Chronic Kidney Disease Stages 3 & 4
Mary El-Assal (2008 – 2012)	Modulation of Cardiovascular Function by Pharmacological Treatments for HIV/AIDS
Sevelanne Gordon (2007 – 2011)	Neuromodulation of Inflammatory Lung Disease
Elias Katsoulieris (2006 – 2009)	Oxidative and Endoplasmic Reticulum Stress in the Kidney
Mohamed Samai (2004 – 2007)	Novel Superoxide Dismutase Mimetics for Protection against Paraquat Nephrotoxicity

Roles

Current and recent roles within the School of Pharmacy & Biomolecular Sciences (PABS), University of 映客直播 include:

Principal Lecturer in Pharmacology
Course Leader: MSc Pharmacology
MPharm Case Study Leader: Renal Failure Case, MPharm Year 2
Module Leader: PY134 – Basic Pharmacology, PYM06 – Oxidative Stress and Human Disease, PYM47 – General Pharmacology, PYM48 – Pharmacology and Drug Discovery (from October 2016), PYM71 – Pharmacology Research Project, QPM55 – Pharmacology and Therapeutics (until September 2016).
MPharm Academic Tutor and MSc Personal Tutor
Internal Examiner: PhD and MRes degrees and the MSc, MPharm and BSc Pharmacol Sci courses
Member of various academic, examination and mitigating circumstances boards within PABS and also at the 映客直播 and Sussex Medical School (BSMS)

External Roles:

Visiting Professor, School of Medicine, University of Belgrade, Serbia
Chief External Examiner, Coventry University
External Examiner, Queen Mary University of London
External PhD examiner (Imperial College London, University of London, Coventry University)
Committee Member: Renal Scientists Working Party (RSWP), UK Renal Association

Other Academic Activities:

Refereeing for journals including the Lancet, Journal of the American Society of Nephrology, Kidney International, British Journal of Pharmacology, British Journal of Clinical Pharmacology, Shock, Cochrane Renal Reviews
Refereeing for grant awarding bodies including: Medical Research Council, British Heart Foundation, Diabetes UK, Heart Research UK, Health Research Board of Ireland, Wellcome Trust
Occasional speaker at charity fund-raising events for Kidney Research UK and Diabetes UK
Fellow of the British Pharmacological Society (FBPhS), American Society of Nephrology (FASN) and Higher Education Academy (FHEA)
Ordinary Member of the Biochemical Society, European Association for the Study of Diabetes (EASD), International Society of Nephrology (ISN) and UK Renal Association.

Awards

'Highly Commended' as 'The Most Supportive Postgraduate Tutor/Supervisor' at the 映客直播 Students’ Union Excellence Awards 2011.